Liposomal Vitamin C

Liposomal Vitamin C is one of the protagonists of the medicine, both from the field of the complementation as from the allopath or simply from the feeding. So today we will dedicate a brief review of "The history" of this great vitamin, because, as we will see, not only covers the treatment of the common cold as many thinks, but the evidence takes far beyond. Liposomal Vitamin C scientific name is ascorbic acid, and it is presented in an innate way in nature. 

This term, ascorbic, comes from the word scurvy which means "Black Death". This is because in the past the majority of the sailors died because of this disease, in which there was a general ecchymosed with hemorrhages both external and internal of all the organs that endowed of black color to the whole body of the person because of the sang Re-extravagated and subsequently coagulated. The explanation for this epidemic at sea was that workers did not consume just fresh food, as they stored frozen food reserves for long boat trips; Basing the diet on meat, fish, eggs, and milk, a group of foods that lacks Liposomal Vitamin C or only has traces of it. In addition, the meat that was dried in salting and always accompanied by potato, a vegetable that loses all its concentration of vitamin C when being cooked.

 

In the eighteenth century, there were already more than 2000 sailors admitted to various hospitals around the world with the diagnosis of scurvy. It was then that a wise admiral found that his sick were cured by remedies such as cider, egg white, and lemon juice. And later it was discovered that this improvement was due to the abundant ingestion of citrus juices, since it is the group of foods with greater richness in Liposomal Vitamin C. Finally, it was in the nineteenth century when definitive treatment of the disease was concluded, consisting of the mere administration of vitamin C and maintained with a correct regular intake of raw and fresh foods.

Its most outstanding physiological properties are the following:

·     It is a hydrosoluble vitamin, this means that it dissolves in water and therefore its field of action is the aqueous medium of the human body, for example, the blood, and does not affect the fatty tissues as is the nervous system. With this, we want to express that it is defined as an antioxidant of all the liquid parts of our organism and not of the lipid parts, in which case the protagonist would be vitamin E.

·    But the fact that it is not an antioxidant of the nervous system does not mean that it does not have an influence on it because it produces an increase in the capacity of mental concentration because it potentiates the synthesis of neurotransmitters linked to this function, as they are Adrenaline and noradrenaline. These two substances also act on the adrenal glands presenting an indirect action on the central nervous system, since Liposomal Vitamin C does not cross the brain barrier of our brain.

This explains that taking an orange at dinner time can reveal the dream, because the intake of vitamin C would produce the increase in the levels of these neurotransmitters and keep us awake for longer, by activating our activity Mental.

·   One of its obvious properties, as we have seen in the introduction, is its anti-scurvy action, as it reconverts the table of Liposomal Vitamin C deficiency. Within this disease the patient presents a weakness of all connective tissue by collagen deficiency, This leads to the decrease of torpor of all our blood vessels, with extravasations of blood out of the venous wall that ends with an endless of internal subcutaneous hemorrhages, called ecchymosed, in addition to a capillary and venous fragility. Widespread.

The diagnosis is carried out by means of a device that applies a pressure higher than 200mm of mercury over a blood vessel, keeping the pressure elevated for a few minutes until the onset of ecchymosed begins. 

If the onset occurs in a few minutes it is diagnosed the disease, ie the lack of vitamin C. In a simpler way you can verify this deficiency in those people who have bruises on the skin to the minimum external blow, this is because their venous walls are excessively weak and any small trauma causes the outflow of blood out of the glass. In which case the treatment would be as simple as the administration of Liposomal Vitamin C, always attached to a dose of bioflavonoid as we explain later.

Vitamin C is also needed for collagen maturation as it acts in the process of transforming Precollege into mature collagen. This process requires several consecutive transformations, and two of them are considered most important, where precisely Liposomal Vitamin C is essential. This is a hydroxylation reaction in which the amino acids pralines and lysine pass into the form hydroxyproline and Hydroxyl sine, which are the basic substrates of mature collagen. Therefore the intake of the complex Liposomal Vitamin C + Hydroxyproline + hydroxylysine improve the status of our collagen as a treatment of both arthropathy and skin problems, hair, nails, etc.

Having a good collagen is thus translated into a healthy skeleton, where bone fractures easily consolidate and there is a good warehouse of minerals important for the joint such as calcium or magnesium since these trace elements are stored Within this collagen nourishing our bones indispensably.

 

With this explanation, we conclude that any fracture should be taken a minimum of 50mg daily Liposomal Vitamin C, as well as for the healing of skin wounds or ulcers of different mucous. On the contrary, if we have low levels of this vitamin the healing processes would lengthen and in specific cases of sprains or tendinitis, the regeneration of collagen would not be optimal.

·    We also find that it plays an important role in relation to cancer. Because when a tumor grows inside the organism, our body is defended in a first phase through its encapsulation, surrounding of connective tissue to prevent it from continuing to grow outside the capsule and become malignant. This is positive provided that the closure of the capsule is complete but negative in the sense that it prevents the recognition of the tumor by our antigens that carry out the activation of the immune system for the purpose of destroying everything that we Hurt. Therefore there are aspects that defend it at this point and others that prefer to discard its use.

What is right to know is that at high doses, even 50gr of sodium ascorbate intravenously through a drop-by-drop serum slowly triggers the activation of cell apoptosis, ie suicide or spontaneous death of tumor cells without Cause secondary inflammation by self-destruction. Then ending with the tumor without any inflammatory reaction. This apoptosis starts up the so-called cytotoxic T8 lymphocytes and the NK (Natural Killer) cells of the TH1 line, which are responsible for the elimination of the detected malignant cells. 

The biggest problem of such high doses is that much of it is not able to pass into the cell and thus is eliminated urinary tract, so be careful with the negative effects of this massive loss of Liposomal Vitamin C through the Kidney.

It becomes then the field of cancer a controversial terrain in the use of this vitamin.

·   His action on the immune system has led us to think about its effects on the antiviral fight for the destruction of the invaded cell. The studies have concluded that it does not act as a preventative of the flu or colds or the common because it does not decrease the frequency of the same when ingested. It also does not help to resolve the picture if you take it once the infection is diagnosed.

Its specific function is focused on that taken regularly, either in the form of supplements or through the daily diet, does not decrease the number of flu per year but it does soften its intensity in the event of infection with the virus, as well as shorten the duration of the symptoms Logy. When the flu has already been implanted it has a slight influence on its remission as long as it is taken at the beginning of the first signs.

There are still two exceptions to all these statements that are the following: 

• The marathoners who are dedicated to running as elite athletes if they take 50mg a day of Liposomal Vitamin C during the 15 days leading up to the race decreases the frequency of the colds provoked throughout the marathon by 40%.

• The second case is the elderly admitted to geriatric institutions, where the intake of Liposomal Vitamin C acts as a preventative of influenza, because the food plans of these centers have abundant dishes cooked in the form of purées or creams where the presence of This vitamin is minimal, causing a subclinical picture of scurvy in many of these elderly people, also caused by an increase in respiratory infections.

Metabolic pathways

Vitamin C is presented naturally throughout our environment, always linked to bioflavonoids that protect it from its easy oxidation, because the contact with oxygen oxidizes it very quickly in a few minutes. This oxygen can be both the present in the air as it is inside our stomach introduced through swallowing. When the vitamin is oxidized and loses its function completely as an antioxidant, so it is so important to eat the whole orange and not in juice because these bioflavonoids are in its white part and also the same process of squeezing already introduces an excess of Oxygen in the fruit. As well as to be aware of the choice of supplements that are always attached to a bioflavonoid complex.

Its absorption occurs in the first part of the digestive tract, producing a maximum elevation peak almost at the time of ingestion. But today there are different presentation options in the field of supplementation, which have managed to maintain an extension in the time of the levels of vitamin C with a single daily intake in the morning.

 

The different forms of Liposomal Vitamin C are: 

• As the ascorbic acid, it is its purest presentation as it is as it is found in nature.
• And on the other hand are the ascorbates, which are the most used in complementation because they do not produce gastric intolerance. Here are:

Potassium, magnesium, calcium or sodium salts. As a disadvantage is that the contribution of Liposomal Vitamin C in these cases is not 100% because they always share a small dose of the mineral that accompanies it, which is usually 20% so that vitamin C is around 80%.

The potassium ascorbate even carries more input from the mineral than vitamin so it is not used as a supplement to vitamin C.

Sodium produces an increase in blood pressure as well as edema, discarding its use.

And then we have the calcium, called Ester-C, which is one of the best sold and better tolerated, since it also achieves a high level of vitamin C maintained throughout the day in a stable way without presenting peaks of elevation and descent within a few hours of administration, As is the case with most of the supplements based on ascorbic acid and lacking bioflavonoids.

There are also lipid forms such as Ascorbyl Palmitate, which is only authorized in Spain at a cosmetic level for the use of various anti-aging beauty creams, therefore not sold as a compliment because it does not allow the legality by the agency Medication.

The process of absorption of Liposomal Vitamin C starts in the liver 

when it produces its entry into the hepatocyte (hepatic cell). In this active point to microsomes, which are enzymatic granules that participate in phase I and II of hepatic detoxication, causing an antioxidant effect. In phase I, cytochrome P450, one of the highest responsible for oxidation processes, participates, and in phase II a wide spectrum of free radicals are released that are neutralized by Liposomal Vitamin C, among other elements of joint participation, producing the Same time an indirect effect of drug purification and different toxins accumulated in this great organ, large waste filter.

The increase of free radicals is associated with an activation of the cascade of production of inflammatory cytokines and it is then that the vitamin C is in charge of inhibiting these cytokines, producing an anti-inflammatory and at the same time analgesic effect.

The dose of vitamin C than an adult organism needs to maintain its minimum levels is 80mg, but if we want to use it as a medicine, ie to treat diseases or prevent various pathologies, then we should raise the dose above this lintel, The most frequent are from 1 to 3gr daily.

Vitamin C only remains in our body 1/3 of the day because it is previously eliminated very quickly when reaching its peak in blood. But if we opt for a presentation of vitamin that is of sustained release (slow), as is the patent Ester-C, we increase its time of permanence.

 

Once absorbed it behaves in a similar way to glucose, that is to say, when it reaches a concrete lintel of blood it is eliminated through the kidneys. Therefore, administered at high doses, above the C.D.R. components. Electronics levels (recommended a daily dose of 80mg per day), it appears in the urine. The ingested dose is directly proportional to its concentration in urine. But the body is intelligent, and when it considers that it no longer needs more, it stops absorbing it to avoid an excess of work by the kidneys, not being therefore possible overdose intoxication. This part not absorbed then passes to the intestinal tract, therefore a dose higher than that our body considers necessary has a laxative effect, because in the intestinal walls is carried out an osmotic process of attraction of water that decreases the Consistency of feces, finally triggering diarrhea. The dose to which this occurs is individual to each person, as it is linked to the amount specified that each organism needs to fulfill its vital functions according to the individual context of the person: The associated pathologies, oxidative processes triggered, the presence of an inflammatory terrain, etc. Precisely the onset of diarrhea would be indicative of the right dosage that each patient requires a maximum level of tolerance. Generically, as a guideline, the maximum usually occurs above the daily 3gr, but there are people who even ingesting 10 or 15gr daily have not noticed any of these effects, which means that they have a large deficit of Liposomal Vitamin C.

In addition to bioflavonoid, another compliment that presents synergy absorptive on vitamin C is Alpha lipoic acid, as the administration of the two together allows a greater intracellular uptake of the vitamin. So with fewer doses, we would get the same effects because we enhance their absorption.

Iron is a mineral that is also benefited by Vitamin C, in this case when we give together we facilitate the assimilation of managed iron within the complex since vitamin C allows the change of its form ferric to ferrous, which is the presentation with Greater organic assimilation.

A similar process also occurs with folic acid, which thanks to the help of vitamin C is transformed into pollen acid, the active form of vitamin B9.

Orthomolecular medicine 

The use of high doses of vitamin C was promoted by Linus Pauling, which deduced that the man was the only animal, along with the Indian bat and the guinea pig, which did not synthesize this vitamin in a physiological way.

The chemical structure of vitamin C is similar to that of glucose as we have already commented, so most animals use glucose to transform it into that vitamin. 

This explains why animals do not require Liposomal Vitamin C supplements in any case, since their own organism is able to produce it innately in the necessary amount. 

The fact that the human being is not able to carry out this transformation from glucose is simply due to a problem of adaptation.

Linus then checked that the daily dosage needed to synthesize the animals was much higher than the one we ingested through the diet every day. In this way, he subsequently deduced the relationship between the deficit of vitamin C and certain degenerative diseases exclusively of the human being and not existing in the animal field. If we take high doses of the vitamin, in a proportion similar to that produced by animals in a physiological way, we protegeríamos of such degeneration. To reach this conclusion he wanted to show it himself by administering the doses directly, as in addition, Linus was a person with a weakened health and a land of frequent infections with low energy efficiency.

 

It was then that the so-called orthomolecular medicine emerged, that is to say, to contribute to the cell the appropriate molecular environment to improve its behavior in a more optimal way and thus increase the physical-psychic performance of the person, extending this definition Not only to the field of application of the vitamin C but to all the other chemical elements that compose the human organism.

The negative part of this theory is that the intake of high doses of an element does not always mean the entry to 100% of that substance within the cell cytoplasm, instead of the animals already synthesize the Liposomal Vitamin C from inside the cell, not by mouth form to external.

It has also been demonstrated with the evolution of the science that the administration of megadoses of vitamin C in a way maintained in the time causes a scurvy of rebound once interrupted the treatment, since the cell defends of such high doses leaving Absorb part of it and when you actually need to administer it externally for a specific pathology the absorption has been nullified. Therefore, it is advisable to use the megadoses for punctual treatments for a specific period of time and controlled at all times by a therapist. and also to unite it always to a complex of folic acid and bioflavonoids that increase the intracellular dose, as is advised for example in oncological treatments.  

• When we administer Liposomal Vitamin C on a non-oxidized field that will later be exposed to oxidative damage, the vitamin acts as an antioxidant to decrease this oxidation in the near future. In other words, we do a prevention therapy against free radicals.
• If it is already oxidized against the soil of the person, the intake of vitamin C further enhances oxidation, as is the case for smokers, who should have contraindicated their administration.
• Finally, if this intake of vitamin C is through food, for example by a diet with abundant crude, in no case there are such contraindications, as the vitamin always acts then as a potent antioxidant. This is because it is surrounded by substances that prevent it from oxidizing within our organism, thus favoring the reactions of neutralization of free radicals.

Foods with high wealth

Within the group of fruits, the most concentrated are citrus fruits such as orange, lemon, grapefruit, kiwi, guava, plum Kakadu, Camu Camu, Rosehip, Acerola, black and red currant, persimmon, papaya, strawberry, melon, grapefruit raspberry, mandarin, mango, and Lima. Always taking into account the proximity of its cultivation, giving preference to the locals in the area where we are because the delicacy of this vitamin favors its loss during long travel transport of imported food from abroad.

In the vegetables and vegetables would be the red pepper as one of the most concentrated; Then there would be parsley, broccoli, Brussels sprouts, cauliflower, and spinach, as the most outstanding.

So two portions of fruit and two salad dishes with a variety of raw vegetables would be the dose of vitamin C that our organism needs daily to carry out its vital functions I do not develop a deficiency scurvy. In the case for example of the Kiwi, a ration would already cover the C.D.R. Componentes Electronicos since 100gr of this correspond precisely to 80mg of Liposomal Vitamin C, but whenever they are offseason and of the zone.

Smokers need 20% more vitamin C in the diet than the rest because they are deficient. For this reason, they have to get used to dressing the dishes with a few drops of lemon juice and putting raw pepper on a regular basis in the salads.

The skin is remarkably hydrated when you consume abundant antioxidants, for this reason, tobacco produces as one of the first symptoms a premature aging of the skin by an increase of its oxidation. When we begin to ingest correct doses of potent antioxidants such as vitamin C the skin is the first indication of its positive effects.

Deficiency symptomatology (Scurvy) 

• Mouth: redness, gum bleeding, periodontitis, dentin demineralization, deformation and increased mobility of the teeth.
• General: Capillary and bone fragility, defects in connective tissue, generalized malaise with fatigue and muscular weakness, dyspnea and anemia.
• Hemorrhagic syndrome: Petechiae and ecchymosis, General hemorrhages of the whole organism even at the level of internal organs and viscera, hematuria and stroke.

Indications based on scientific evidence

Evidence to

• Vitamin C deficiency or scurvy.

Evidence B 

• Prevention of the common cold in marathoners and people who practice extreme sports like cross-country skiing.
• Urinary tract infection during pregnancy
• Increased iron absorption.

Evidence C

Cancer:

• Breast, endometrial, colorectal, and prostate cancer.
• Protective and adjuvant during chemotherapy application.
• Prevention and treatment of malignant tumors.

Cardiovascular: 

• Treatment of ischemic heart disease.
• Stroke.
• Chronic venous insufficiency.
• Hypertension.
• Anemia.
• Erythropoietic Protoporphyria.
• Hyperlipidemia.
• Various metabolic abnormalities, including metabolic syndrome or X syndrome.
• A base treatment of frequent or difficult-to-referral spontaneous hematomas caused by a weakness of the capillary walls.

Skin and connective tissue: 

• Scarring of Burns.
• Remission of solar erythema.
• On a topical level for the treatment of pressure or decubitus ulcers.
• Prevention of wrinkles and spots on the skin by hyperpigmentation.

Inflammatory terrain: 

• Application in different types of arthritis and some varieties of arthrosis.
• Vaginitis.
• Asthma, for its antihistamine effect.
• Cystic fibrosis.
• Lung disease of various kinds, as well as pneumonia.

 Renal-hepatic axis: 

• Treatment of type II diabetes mellitus and prevention of consequent diabetic retinopathy.
• Contrasting nephropathy.
• proteinuria.
• Vesicular or hepatic disease.
• Lead-cluster toxicity.

In the field of the nervous system: 

• General improvement of Parkinson's or Alzheimer's disease.
• Autism.
• Treatment of Subdeck syndrome with sympathetic-reflecting dystrophy associated with a previous fracture with poor evolution.

In infections:

• Implantation of Helicobacter Pylori.
• HIV Aids Virus.

In other sectors:

• Decreased mortality from chronic diseases.
• Optimization of the months of pregnancy.
• Treatment of the premature child.
• Better tolerance to the administration of nitroglycerin and its derivatives.
• Prevention of macular degeneration.
• Physical recovery after an intense exercise session.
• Potent analgesic in the field of pain medicine, because in these patients their reserves are exhausted.

D-Evidence, i.e. with contradictory results.

• Prevention and treatment of the common cold.
• Prevention of cardiac pathologies, on the contrary, if we refer to your treatment yes that presents evidence C as we have captured. 

Precautions in your administration

According to our explanations based on the experimental literature, we become aware of the importance in the precise choice of the dose at the time of its specific therapeutic indication, with possible onset of diarrhea from the 3gr. Although we already know that this number is always tentative and conditional in each case.  In addition, since Liposomal Vitamin C is largely eliminated by the kidney in the form of oxalates, no more than 50mg per day should be given in patients with renal lithiasis by oxalates.

It happens exactly the same in the case of having kidney failure, to avoid an excess of work for the kidney when trying to eliminate the excess amount. 

They do not have to take Liposomal Vitamin C supplements because of the consistent ferrous absorptive synergy. There is a case in the literature where it is recorded that a dose above 4 ' 5gr/day produces an increase in glucose in the diabetic patient due to its similarity with the glucose molecule. This is because glycosuria (elimination of glucose through urine) is then inhibited and thus increases glycemia (blood glucose level). But, as we will describe, it is a very particular case. Throughout the entire experimental history with the vitamin in its different uses.

People with a deficiency of the enzyme glucose-6-dehydrogenase, that is, favism disease; Nor should they ingest vitamin C supplements as this is a type of hemolytic anemia.

Pharmacological interactions 

• We should not take it together with anticoagulant drugs such as "sintered", as we will increase the risk of bleeding.
• It also potentiates the effect of the taking of amphetamines, because both are brain stimulants similar to adrenaline and noradrenaline.
• If administered together with the application of chemotherapeutic may decrease the effects of cancer treatment, as it increases phases I and II of metabolism of toxins by the liver.
• Therefore, since there is no consensus at this point, the most correct thing would be to avoid their indication or to study the case widely and based on the last generation studies.
• Finally, it can also enhance the effect of oral corticosteroids.

Smokers have to increase the intake of Liposomal Vitamin C because they have their reserves depleted because of the generalized oxidative terrain they present. But in these patients, the ingested dose must always come from the food itself and not in the form of supplements.

Healthy people have to boost their consumption through a wide variety of raw fruits and vegetables suitable for each seasonal season. And at the same time, the complementation should be reserved for specific treatments or people with deficiency due to a pathological cause. In this way, it will be as we will stay only with the broad positive part of its therapeutic recommendation and leave aside its possible risks for excess or malpractice.

This is because Liposomal Vitamin C, like any other chemical element, is not exempt from precautions, so it has to be used under the supervision of our therapist and sustained in a clear indication, not automatically. When such an indication is real then we will benefit from its great results quickly and even surprisingly.

If we opt for orthomolecular medicine the doses can reach 20 or 30gr daily, sold in jars of 0 ' 5kg of ascorbic acid powder. It is thus a treatment limited in time and duly argued by a therapist, only thus presents benefits above damages.

The most current evidence recommends doses of around 500 or 2000mg daily and in some cases 3gr, as doses of more therapeutic use and maximum effectiveness.